The Main block was built in two years by Messrs. Schilling and Turner Company. To put up the Main block each member of the Gold Coast Methodist Church contributed five shillings while the prominent and generous donors who immensely supported the construction of the Main block need to be mentioned here. They were Mr. Knight, a businessman and Mayor of Newark, United Kingdom and Mr. Brew, a Methodist businessman from Cape Coast, Ghana.
When the main block was completed the College was transferred from Aburi to Kumasi. On Monday 3rd March, 1924, Wesley College was officially opened in Kumasi.
Current facilities available to staff and students to facilitate access to information in a serene environment for academic works on campus are listed below:
| S/N | COLLEGE FACILITIES |
| 1. | Rt. Rev. Dr. E.H. Brew-Reverson Hall |
| 2. | S.H. Amissah Building (Administration Block) |
| 3. | J. Eshun-Famiyeh Computer Centre |
| 4. | Science Laboratory |
| 5. | Dr. K. A. Busia Library |
| 6. | Guidance and Counseling Centre |
| 7. | Dining Hall |
| 8. | Six Classroom Blocks |
| 9. | Resource Centre |
| 10 | Market |
| 11. | Wesley College Gym & Fitness Centre |
| 12. | J.E.K Armah Conference Room |
| 13 | Halls of Residence |
| 14. | Stores |
| 15. | Playing Fields |
| 16 | Sick bay |